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Mimetis hero image

Mimetis

Favourite

Mimetis logo tiny

We design & manufacture naturally inspired biomaterials for bone regeneration in dental and orthopaedics.

Location
Barcelona, Spain
www.mimetis.com

Categories: Healthcare Non-Digital Mixed B2B/B2C

Investment
sought:
€120,005
Discount
offered:
20.00%
Funded 14 Nov 2018
Investment
amount:
€190,443
Valuation
(pre-money):
Convertible
  • Overview
  • Idea
  • Market
  • Team

Team

  • Img 9945r sq
    David Pastorino
    Board Member
  • Img 6992r sq
    Ana Chinea
    CEO
  • Maria pau ginebra  1
    Maria Pau Ginebra
    President, Co-founder
  • Carlos aparicio  1
    Carlos Aparicio
    Investor, Opinion Leader in dental implantology, Board member.

Learn more about convertible campaigns.

Idea

Introduction

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Mimetis designs, manufactures and commercialises bone regenerative solutions in the dental and orthopaedic fields.

The company was incorporated in 2013 as a spin-off of the Technical University of Catalonia, Barcelona, with Dr.Ginebra as the spearhead and acting President.

Mimetis uses biomimicry as its technological inspiration, synthetically manufacturing a bone graft that closely mimics the natural bone of the patient in order to regenerate it physiologically.

As of today, Mimetis is up and running with its own manufacturing line, increasing sales revenues and an experienced team onboard.

The company is now:

- Expanding its portfolio of bone regenerative solutions with a unique 3D Printing technology for patient-specific implants.
- Growing commercially towards orthopaedics and additional territories.

Mimetis 12

Convertible Details

This investment round is being raised by way of a convertible instrument. The key terms that apply to the Mimetis convertible are as follows:

• Discount – conversion at a 20% discount to the valuation set by a Trigger Event.

• This convertible has a valuation cap of €10m. Please note that the discount does not apply to the valuation cap. If the Trigger Event is at a valuation of more than €10m, then the convertible will convert at the lower of:
- the price set by the Trigger Event less the 20% discount; and
- a valuation of €10m.

• Conversion is triggered by the follow Trigger Events:

o An Equity Fundraise – defined as the Company raising investment capital of at least €800,000 from one transaction or a series of transactions, in exchange for the company issuing equity Shares. The Seedrs fundraise does not count as a transaction.

o A Change of Control of the company (transfer of more than 50% of the share capital); or

o An IPO – being a listing of the company’s shares on a recognised stock market or secondary market.

• The Longstop Date is 12 months from the date of the convertible agreement. If conversion has not been triggered by the Longstop Date shares will be issued on the Longstop Date at a valuation based on the lower of:
(i) the lowest price of any Equity Share issued after the date of this Agreement; and
(ii) a pre-money company valuation of €3,666,985 on a fully diluted basis (this is based on the valuation of Mimetis' last funding round).

The convertible would also convert to equity at this price in the event of winding up or liquidation of the company.

Intended impact

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Global ageing is a clear trend and is linked to a growing need for bone regenerating solutions. In the dental field, bones need to be regenerated or replaced before placing a dental implant. In the orthopaedics field, bone grafting is used in spinal fusion procedures.

The existing solutions have limitations such as:
• Ethics: Animal- or human-derived bone grafting solutions raise major ethical, cultural or religious issues.
• Efficacy: The existing solutions are biomaterials for bone filling instead of temporal tools for physiological bone regeneration.
• Anatomy: Existing solutions do not allow implantation of biomimetic patient-specific bone regenerative solutions

Mimetis serves the unmet needs developing and marketing the latest generation of bone regenerative solutions. This pursues a triple aim (better care, better health, lower cost), and the medical providers’ specific objectives around quality, safety and cost.

Here is some educational content for patients on how bone grafts work:

Substantial accomplishments to date

Img 7121 169 contrast 16x9 tinypng

To date, Mimetis reached the following milestones:

• Technological background
- A team with the benefit of 15 years of academic research into the workings and discovery of biomedical engineering.

- Regulatory approvals for Europe have been received (CE, ISO13485). To our knowledge this is the first biomimetic product in the market.

• Product & Commercial traction
- Our view is that the existing synthetic solutions may solve ethical concerns but lack clinical efficacy. Mimetis’ aim is to use innovative biomimetic technology to provide patients with ethical, synthetically sourced, clinically-efficient bone regenerative solution.

- A patient-specific, biomimetic 3D-printed bone regenerative solutions for complex cases: MimetikOss 3D.

- Global option agreement in the dental field

- National increasing sales year on year

- 200k in Sales (Product & Services).

• Financials/Corporate
- €800k of funding from founders and strategic investors

- €1M of grants from the European and Spanish institutions.

- €128k accumulated tax credit.

- Dr.Maria Pau Ginebra was a finalist of the Women Innovator Prize organized by the European Union 2018.

Monetisation strategy

1

Mimetis Biomaterials designs, manufactures and commercializes bone regenerative solutions. MimetikOss Granules' design is based on biomimicry to regenerate bone. The product is available in European markets. The company manufactures the granules using a proprietary trade secret in an ISO7 cleanroom at its manufacturing site based in the outskirts of Barcelona, Spain. Also, it owns a customised 3D-printing set of machines to print personalised bone grafts.

The company’s sources of revenue are:
> Direct sales in dental and orthopaedics (Spain)
> Sales through sales representatives (Dental, Spain)
> Sales through distribution agreements (Orthopaedics, Spain)
> Upcoming option agreement in place (Confidential)
> Services provided to dental implant companies

Use of proceeds

Mimetis 14

The funds gathered support the first step taken towards a larger investment 2019. It will help us to reach key objectives such as:

> The 1st human case using 3D-printed biomimetic technology
> Intermediate results of the ongoing randomized clinical trials
> Potential execution of a global option to exclusive distribution in the dental field
> Initial orthopaedic market entry
> Packaging update to match orthopedics needs

All the aforementioned items are high-value areas for the company. The 6th activity of the Company during this time span is the preparation of this Series A investment round.

Subsequently, the amount raised in the campaign would allow for continuing development of the company. Mimetis have two soft bank loans of €100k each. The loans will be fully reimbursed Q2 2019 but this fundraising round will not be used to pay back these loans.

Market

Target market

Cover seedrs mimetis biomaterials  1

Our users are technical buyers, with deep understanding and knowledge of bone regenerative solutions:

• Dental surgeons: Bone grafting accompanies dental implants.
• Orthopaedic/Craniomaxillofacial surgeons: Spinal fusions and bone regenerating procedures are increasingly common and linked to global healthy ageing needs in developed countries. Furthermore, patient-specific 3D-printed scaffolds prevent bone harvesting from the patient. The orthopaedic/CMF market is 4 fold the dental market globally.

In both markets, the appeal of the product is its uniqueness in the market being the first biomimetic bone regenerative solution as far as we are aware. Its clinical efficiency and synthetic sourcing are valued by customers.

Characteristics of target market

Mimetis is intended to have a global presence, with a special focus on Europe where 2 million bone grafts are performed each year. The EU BGS market is predicted to rise from $721m in 2016 to $1055m by 2025 (European BGS market forecast 2017-2025, Global Inf Inc Research).

The promising results in the dental sector support our vision to introduce a disruptive technology into craniomaxillofacial (CMF) and orthopaedics through patient-specific solutions.
Key market data is provided:
• Dental Bone Graft: A market worth $664m globally by 2021.
• CMF: The global CMF implants market is expected to grow at a CAGR of 6.2% from 2014 to 2020, to reach an estimated value of M$1498.6 in 2020 (Persistence Market Research study ‘Global Market Study on Cranio Maxillofacial Implants’, 2014).
• Orthopaedics: The orthopaedics market, 80% of the total global bone grafting market, is more mature, grows at a CAGR of approx 4.1%.

Marketing strategy

Mimetikoss injerto o seo sinte tico caja

Mimetis commercializes its products in Spain through both direct sales and 15 external sales representatives. Our goal is to reach commercial agreements with medical devices distributors in the orthopaedic field (cost-effectiveness of the sales process, access to public calls...).
Our go-to-market strategy for patient-specific and standard products is the following:
• Lead generation through social media, website, newsletters and conferences.
• Technical adoption: using exceptional clinical and objective validation of the products and support from Key Opinion Leaders.
• Commercial adoption: price/volume negotiations to make the most of the direct manufacturer-distributor relationship.
• Loyalty: Tight follow-up of the customers and maintenance of high-quality standards (Mimetis is ISO 13485 Certified by BSI).

Competition strategy

Sources seedrs 2

As of today, the market is dominated by allografts (human-derived, preferred option in the US) and xenografts (animal-derived, preferred option in the EU). Our company differentiates using a biomimetic technological basis. It seeks to support it with exceptional clinical evidence.

• The competitive landscape for bone grafts substitutes (granules) includes:

- Ceramics (Zimmer Biomet, Teknimed)
- Coral (Corebone, Zimmer-Biomet, Biocora, Interpore)
- Composites (Insubri,Stryker)
- Demineralized bone matrix (DBM, Zimmer-Biomet, Allosource, XTANT Medical, SeaSpine),
- Xenografts (Straumann, Geistlich Pharma, Zimmer-Biomet)
- Allografts (DePuy Synthes, Strauman, Zimmer-Biomet)

• The competitive landscape for patient-specific products includes direct competitors (Xilloc, Innotere, Tissue Regeneration Systems) and substitutes solving the same problem (Depuy Synthes, KLS Martin).

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Investing involves risks, including loss of capital, illiquidity, lack of dividends and dilution, and should be done only as part of a diversified portfolio. Please read the Risk Warnings before investing. Investments should only be made by investors who understand these risks. Tax treatment depends on individual circumstances and is subject to change in future.

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Seedrs Limited is authorised and regulated by the Financial Conduct Authority (No. 550317).

© Seedrs Limited 2019. All rights reserved. Seedrs is a registered European Community trademark (No. 008771537) and registered United States service mark (No. 85423072) of Seedrs Limited, a limited company registered in England and Wales (No. 06848016), with registered office at Churchill House, 142-146 Old Street, London EC1V 9BW, United Kingdom, VAT No. GB 208 3065 32. Seedrs.com is a website owned and operated by Seedrs Limited.

This business is eligible for SEIS relief - providing qualifying investors with income tax relief of 50% of their investment and certain other tax reliefs. Tax treatment depends on individual circumstances and is subject to change in future. Click to learn more.
This business is eligible for EIS relief - providing qualifying investors with income tax relief of 30% of their investment and certain other tax reliefs. Tax treatment depends on individual circumstances and is subject to change in future. Click to learn more.